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KMID : 0352519920290010365
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Korea Univercity Medical Journal
1992 Volume.29 No. 1 p.365 ~ p.378
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An experimental study of the effects of halothane and enflurance anesthesia on the liver function of rats pretreated with ethyl alcoho
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장원영:
저자없음:No authors listed
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Abstract
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The effects of two inhalation anesthetic agents on liver function were compared in male Sprague-Dawley rats pretreated with ethyl alcohol. Blood sampling was done before intravenous injection of ethyl alcohol (400 mg/kg) or saline (5 ml/kg)
through tail vein of 78 rats, And 24 hours later, all rats were randomly assigned to receive one of two anesthetic managements for two hours : 1) halothane-nitrous oxide-oxygen : 2) enflurane-nitrous oxide-oxygen : Blood sample and hepatic tissue were obtained 24 hours or 96 hours after anesthesia. Measurements of hepatic function (protein. albumin, cholesterol, total bilirubin, direct bilirubin, asparate aminotransferase, alanine aminotransferase. alkaline phosphatase. BUN. creatinine) were made and hepatic tissue was examined with light microscopy.
The results are as follows:
1. There was no significant difference in the laboratory finding between the saline and alcohol group.
2. Most laboratory findings 24 hours after anesthesia revealed decreased levels in all groups but the level of ALT in enflurane control group was increased.
3. Most laboratory findings 96 hours after anesthesia also showed decreased level in all groups but the levels of bilirubin and ALT in enflurane group. AST in enflurane control group were increased.
4. There was no difference in histologic injury in both group 24 and 96 hours after anesthesia.
From the above results, it can be concluded that pretreatment with alcohol does not have any significant clinical effect on the liver after halothane or enflurane anesthesia.
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